One reason I like digital coloring so much is that it's unpredictable... therefore more interesting. I think it's a fun game of cat and mouse to take a chance on a new brush or try a new technique. There's always the undo button.
So on any given day, the digital artist is free to try whatever they like. Today I've been choosing those natural media brushes that start around 750 pixels in size. It's always interesting to see what they might do!